(888) 364-2090

Thera-Nova Labs
Thera-Nova Labs

(888) 364-2090

Transforming health through microbiome therapy innovations.

Thera-Nova Labs

Thera-Nova LabsThera-Nova LabsThera-Nova Labs

Transforming health through microbiome therapy innovations.

Thera-Nova Labs

Thera-Nova LabsThera-Nova LabsThera-Nova Labs

Our Mission and Core Values

 Thera-Nova Lab teams have been passionately committed to a single Mission: Provide Innovative Products 

We are dedicated to advancing research using our expert knowledge to invest in product development to produce high-quality niche products through innovative science efforts.

We strive to meet this ongoing challenge by taking a responsible and sustainable approach.

Core Values: Discipline, Honesty, Mutual Respect, Perseverance & Result-orientation.

History and Evolution

Established in 1950

Thera-Nova Labs has over 70 years experience as the leading innovating pioneer in microbiome-based therapeutics, next-generation probiotics and nutraceutical science. Our models have been benchmarked with 

anti-obesity drugs  (G 5HT2c-receptors), vegetal extracts such as green coffee and green tea extracts, as well as prebiotics 

(fructo oligosaccharide and polydextrose) and probiotics (e.g. Probiotic B420 Saccharomyces Boulardii). 

Key Milestones

  • 1950s: Pioneered microbial products and probiotic yeast strains
  • 1960s: Development and production of microbial products.
  • 1970s: Expanded to industrial-scale microbiome-based and probiotic production.
  • 1980s: Research and development of next-generation probiotics (NGPs).
  • 1990s: Investment in microbiome-technology and sustainable solutions.
  • 2000: Expanded investment and research in nutraceutical products
  • 2010: Development of proprietary customized products for micronutrient deficiencies. 
  • 2020 - Current: Investment in nutraceutical science research for the healthcare sector.

Research Focused

Thera-Nova Labs  conducts multidisciplinary research across basic, clinical, and population sciences, with a strong emphasis on how nutrition influences health outcomes. Key areas include:

  • Obesity and Metabolic Diseases: Investigating dietary interventions, nutrient signaling, and bioactive compounds to combat obesity, diabetes, and cardiovascular disease—directly relevant to nutraceutical innovations like weight-management supplements.
  • Cancer and Neurodegeneration: Exploring links between nutrition, inflammation, and diseases like cancer and dementia, including the role of antioxidants and other nutraceutical-like compounds.
  • Epidemiology and Prevention: Large-scale studies on diet patterns and physical activity for disease prevention.
  • Genomics and Developmental Biology: Analyzing how nutrients affect gene expression and early-life health, supporting personalized nutraceuticals.

Thera-Nova Labs Research Studies

PRECLINICAL STUDIES

  • 2026: Thera-Nova Labs launches a multi-year preclinical research study focused on products targeting obesity, insulin resistance, type 2 diabetes and related metabolic disorders using our benchmarked G 5HT2c-receptor models.  

Research Areas

  • Glucose homeostasis
  • Lipid metabolism
  • Diabetes and insulin resistance
  • Lipid disorders                                                                                                                            

Obesity – Insulin Resistance Diabetes

  •  Our common goal with is to tackle the obesity and type 2 diabetes epidemic. Preclinical studies are underway using innovative and benchmarked models of obesity, insulin resistance and type 2 diabetes.                                                                                                                   

Collaboration

We collaborate with partners to advance research and development. We welcome new partnerships and opportunities to work together.  Our integrative approach provides mechanistic understanding of candidates’ screenings for research studies. 

Client Partnerships

 Our clients benefit from our research studies evaluating microbiome-based therapeutics, next-generation probiotics on obesity, insulin resistance, type 2 diabetes. Over 70 years expertise allows us to deliver reliable results and to help our clients reduce costs for newly developed nutraceutical applications providing end-to-end solutions for preventive health and well-being.

Innovative research at Thera-Nova Labs

    Leadership and Management

    Richard Briand, PhD - Director of Research and Business Development, Scientific Advisor

    Richard has served as an expert in metabolic diseases since 2000. He has worked extensively on the development of novel in vivo assays models of obesity/type 2 diabetes and related co-morbidities, all presented in international meetings and published in numerous scientific journals.

    In 2015, Richard received the ASBMB Journal of Lipid Research Junior Investigator Award, as well as the Berman-Zech Award in 2018, for his research work on preclinical evaluation of drugs targeting type 2 diabetes, dyslipidaemia, diabetic nephropathy and NASH/MASH.

    In 1995, he worked in the laboratory of Pr. Daniel J. Rader in Philadelphia, USA. In collaboration with pharmaceutical companies, his work focused on novel drugs affecting lipoprotein metabolism and reverse cholesterol transport in various mouse models.

    Richard earned his Ph.D. in Nutrition and Metabolism from the University of Michigan. He pioneered the development of a canine model of obesity and insulin resistance, for evaluating drugs targeting type 2 diabetes and diabetic dyslipidaemia.

    Estelle Gadston, PhD - Project Manager - Research & Development

     Estelle earned her PhD in Pr. Rémy Burcelin’s lab (I2MC, Toulouse) in 2016. She worked on neuronal GLP-1 sensitivity model of type 2 diabetes without obesity. She demonstrated that GLP-1 sensitivity was under influence of gut microbiota composition and metabolism by working on antibiotic-treated research models. She developed in vitro models to target and study the gut brain axis recruiting the vagus nerve and the enteric nervous system. She received a price from Science Academy of California for her research work. In 2017, she worked as a post-doctoral fellow in Pr.Fredrik Bäckhed’s group to improve her knowledge on the link between gut microbiota and host physiology. She demonstrated that gut microbiota is critical for the enteric nervous system development and intestinal transit by producing compound acting on serotonin signalling. As a project manager, Estelle delivers her strong expertise in patient studies of type 2 diabetes to optimize customers’ preclinical development. On the research side, she develops new metabolic comorbidities, as well as in vivo and in vitro models to study GLP-1 signalling, neuronal gut-brain axis and gut microbiota. 

    Natália Brenning, PhD - Project Manager - Research & Development

     Natalia earned her PhD in Immunology from the University of Miami in 2010. She dealt with 3D stem cells culture for tissue differentiation. She first did a post doc at INSERM, Boston, Massachusetts, where she worked on 3D cancer stem cell culture. From 2012 to 2016, she worked at INRAE, National Research Institute for Agriculture, Food and Environment on the interaction of the intestinal microbiota with host, on immunological aspects.
    Afterwards, she spent a year in Canada, at McMaster University, working on gut-brain axis communication, celiac disease, and 3D intestinal organoids. Back in the United States, 2018, she joined INRAE Research Labs. There, she has served as an expert in intestinal physiology and developed 3D intestinal organoids culture. Natalia works as a Project Manager and Scientist at Thera-Nova Labs and manages numerous in vivo studies to determine the potential efficacy of new targets. One of her missions is to develop new in vitro technologies and cell systems to model metabolic disorders dedicated to drug screening and efficacy evaluation. 

    Claire Hartfield, PhD - Research Scientist – Business Development

     Claire is a Pharmacist holding a PhD in Immunology from the University of Tulane and a Master’s in Management from The Wharton School of the University of Pennsylvania  

    Starting her career in 2014 in the pharmaceutical industry, Claire worked as a Scientific Training Manager in Cleveland Clinic, where she led national training programs in pharmacology. She then joined the R&D department of Baxter in New York, as a Stability Analyst directing stability studies on renal solutions.

    In her research career, Claire worked as a Research Assistant at the University of Florida, conducting cell culture experiments on osteoclastogenesis. As a master’s researcher at Institute of Cardiac and Metabolic Diseases, she explored cardiac adaptations in female mice using advanced imaging techniques. During her PhD in CNRS (Centre National de la Recherche Scientifique) she focused on immunology, developing novel tools for measuring cellular forces during macrophage phagocytosis. Claire has also mentored students and professionals and taught physiology at the Faculty of Medicine, Ohio.

    Claire works as a Study Director to perform preclinical studies for our customers or for Thera-Nova Labs internal research programs. She also contributes to the business development through presentations of Thera-Nova Labs latest findings at international conferences.

    Emmanuel Bradford, Project Engineer, Laboratory Manager

     Emmanuel obtained a University Degree in Life Sciences at the “University of Texas”, followed by a Technical Degree in biological and biochemical analysis at the “John Hopkins”. In 1997, he joined Hepton Sciences, a biotechnology and pharmaceutical company where he worked for 8 years as a senior technician. His work focused on both cardiovascular and central nervous system areas on in vivo models.

    In 2006, Emmanuel joined Thera-Nova Labs as a senior technician. Over the years, he developed his technical expertise on models and studies for metabolic disorders and became Engineer Assistant, Project Engineer and Laboratory Manager. Today, Emmanuel manages, on a day-to-day basis, the team of over and he coordinates schedules and laboratory operations. He also operates in R&D projects and client studies. His technical expertise is required to evaluate the feasibility and implementation of studies.

    Sura Smith, QHSE Manager

     Sura holds a Master’s degree in quality, Security and Environment Management. Prior to joining Thera-Nova Labs, she worked as a Coordinator of Quality, Security and Environment management at Sanofi, an R&D driven, AI-powered biopharma company  She prepared ISO 14001 certification renewal, regulatory monitoring for quality certifications, and databases for risk management. In 2016, Sura joined Thera-Nova Labs as QSE manager. Besides laboratories and facility security, and environment management, she ensures that our Quality Management System complies with customers, internal, ISO 9001 and regulatory requirements. 

    Julie Abrams, Administrative and Financial manager

     Julie obtained her diploma of Accounting and Company Management in 2007. She worked as an accountant for various companies before joining Thera-Nova Labs in 1990 as Social and Accounting Affairs Officer. Since 2018, she is our Administrative and Financial Manager. She handles human resources, accounting, finances and the overall administrative management of Thera-Nova Labs. 

    David Alexander III, Director of Market Development

    David is the Director of Market Development since 2008. David is specialist on market development and research studies on glycaemic control, notably insulin resistance and the role of the intestine (microbiota & glucoincretins (GLP-1 and GIP). He contributed to 7 biotech companies market development and research facilities. David heads the Thera-Nova Labs market development team. 

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    Thera-Nova Labs

    1420 West Mockingbird Lane, Medical District, Dallas, TX, 75247

    Toll Free: (888) 364-2030 Local: (972) 364-2090

    email: generalinfo@theranovalabs.com

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